Cmoat Canalicular Multispecific Organic Anion Transporter Medical , Pathology , BiochemistryLooking for the definition of CMOAT?Bilirubin glucuronide is a watersoluble reaction intermediate over the process of conjugation of indirect bilirubin Bilirubin glucuronide itself belongs to the category of conjugated bilirubin along with bilirubin diglucuronide However, only the latter one is primarily excreted into the bile in the normal setting
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Comatose lyrics-Mix allpurpose joint compound to about the same consistency as mud you would use for bedding tape (the consistency of mayonnaise, or just thin enough to roll on the wall) Pro tip You'll get shrinkage if you mix it too wet Spread a layer of slightly thinned allpurpose joint compound on the walls with a heavynap rollerCMOAT encodes an ATPase within the family of cMOAT/MRP ATPases that functions as an ATP dependent, multispecific anion transporter within the canalicu
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COMAT Distinctive subject examinations designed to assess core osteopathic medical knowledge A series of nationally standardized subject exams, COMAT exams are designed to assess osteopathic medical students' knowledge and ability in core osteopathic medical and foundational biomedical sciences principlesAnd cMOATmediated transport of oxidized GSH, steroid glucu ronides and leukotrienes (3, 6) The recent cloning of the rat (1012) and human (14) cMOAT genes has demonstrated that cMOAT and MRP are different genes that are located on different chromosomes Both are expressed in the liver (1012, 14), with cMOAT beingFind SigmaAldrichSBVT14 MSDS, related peerreviewed papers, technical documents, similar products & more at SigmaAldrich
Cmoat Canalicular Multispecific Organic Anion Transporter Medical , Pathology , BioengineeringOverexpression of the cMOAT transcript has been described in cisplatinresistant cell lines ( 9, 12) , and transfection of an antisense cMOAT construct was reported to confer enhanced sensitivity to cytotoxic drugs ( 13) In addition, a cMOATdeficient rat was reported to exhibit reduced biliary clearance of methotrexate ( 14) TheseFrom sectionals and recliners to bean bags and rocking chairs, these oversized couches and chairs are so comfortable, you'll never want to get up
According to the Association for Intelligent Information Management, document management software "incorporates document and content capture, workflow, document repositories, output systems and information retrieval systems Also, the processes used to track, store and control documents" (1)The cMOAT/MRP2/ABCC2 protein is encoded by a singlecopy gene, MRP2/cMOAT/ABCC2, on chromosome 10q24 15 The conjugated hyperbilirubinemia observed in DubinJohnson syndrome results from defective transport of bilirubin glucuronide across the membrane that separates the hepatocyte from the bile canaliculiSynonym ABC30, CMOAT, MRP2, MRP2 human membrane vesicles, multidrug resistance protein 2;
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A gene on chromosome 10q24 that encodes a protein of the MRP subfamily of the superfamily of ATPbinding cassette (ABC) transporters, which transport various molecules across extra and intracellular membranes, many of which are involved in multidrug resistanceThe cMOAT/MRP2/ABCC2 protein is encoded by a singlecopy gene, MRP2/cMOAT/ABCC2, on chromosome 10q24 15 The conjugated hyperbilirubinemia observed in DubinJohnson syndrome results from defective transport of bilirubin glucuronide across the membrane that separates the hepatocyte from the bile canaliculiMultidrug resistanceassociated protein 2 (MRP2) also called canalicular multispecific organic anion transporter 1 (cMOAT) or ATPbinding cassette subfamily C member 2 (ABCC2) is a protein that in humans is encoded by the ABCC2 gene
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Cmoat Canalicular Multispecific Organic Anion Transporter Medical , Pathology , BiochemistryBilirubin glucuronide is a watersoluble reaction intermediate over the process of conjugation of indirect bilirubin Bilirubin glucuronide itself belongs to the category of conjugated bilirubin along with bilirubin diglucuronide However, only the latter one is primarily excreted into the bile in the normal settingCOMAT Distinctive subject examinations designed to assess core osteopathic medical knowledge A series of nationally standardized subject exams, COMAT exams are designed to assess osteopathic medical students' knowledge and ability in core osteopathic medical and foundational biomedical sciences principles
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Find out what is the full meaning of CMOAT on Abbreviationscom!Human cMOAT was mainly localized in the plasma membrane of CHO/cMOAT and in the apical membrane of LLC/cMOAT The ATPdependent uptake of leukotriene C4 (LTC 4) into CHO/cMOAT membrane vesicles was enhanced compared with empty vector transfectants Km values in CHO/cMOAT membrane vesicles were 024 μM for LTC 4 and 175 μM for ATPDocument management is a system or process used to capture, track and store electronic documents such as PDFs, word processing files and digital images of paperbased content
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An inhibition study of the ATPdependent uptake of the glutathione conjugate, 2,4dinitrophenylSglutathione (DNPSG), a typical substrate for cMOAT, was performed in order to differentiate among the affinities of six quinolone antibiotics for this transporterIn the rat, two Mrp isoforms have been identified, Mrp and cMrp cMrp, also called Mrp2 or cMoat (canalicular multispecific organic anion transporter), is expressed in the canalicular membrane of rat hepatocytes and mediates the excretion of glucuronate, sulfate, and glutathione conjugates into bileExpression of γglutamylcysteine synthetase (γGCS) and multidrug resistanceassociated protein (MRP), but not human canalicular multispecific organic anion transporter (cMOAT), genes correlates
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CMOAT stands for Canalicular Multispecific Organic Anion Transporter Suggest new definition This definition appears frequently and is found in the following Acronym Finder categories Science, medicine, engineering, etc Other Resources We have 1 other meaning of cMOAT in our Acronym AtticIn CMVs prepared from SD rats, but not from EHBR, amarked ATPdependent uptake of 3 HE 2 17βG was observedMoreover, E 2 17βG competitively inhibited the ATPdependent uptake of 3 H2,4dinitrophenylSglutathione (DNPSG)Expression of γglutamylcysteine synthetase (γGCS) and multidrug resistanceassociated protein (MRP), but not human canalicular multispecific organic anion transporter (cMOAT), genes correlates
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The most extensively studied member of this family is cMOAT, the canalicular Multispecific Organic Anion Transporter The substrate specificity of this pump was originally defined by an inborn error in rats, lacking this protein These rats are mildly hyperbilirubinemic, because of their inability to secrete bilirubin glucuronides into their bileFind out what is the full meaning of CMOAT on Abbreviationscom!The human MRP2/cMOAT gene contains 32 exons, and it has a structure that is highly conserved with that of another ATPbindingcassette gene, that for a multidrug resistanceassociated protein We then identified three mutations, including two novel ones All mutations identified to date are in the cytoplasmic domain, which includes the two ATP
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The canalicular multispecific organic anion transporter (cMOAT), also termed multidrug resistanceassociated protein (MRP2) or canalicular multidrug resistanceassociated protein (cMRP), is a membrane transporter predominantly found at the biliary pole of hepatocytes ( 1, 2)This 190 kDa protein mediates the passage of various types of organic anions, including glucuronate, sulphate andCMOAT Canalicular multispecific organic anion transporter Homo sapiens (Human) CMOAT gene & protein UniProtKB Q9UN90 (Q9UN90_HUMAN)Coadministration of Probenecid, an Inhibitor of a cMOAT/MRP like Plasma Membrane ATPase, Greatly Enhanced the Efficacy of a New 10Deazaaminopterin against Human Solid Tumors in Vivo F M Sirotnak, H Guido Wendel, William G B Bornmann, William P Tong, Vincent A Miller, Howard I Scher and Mark G Kris DOI Published September 00
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Multidrug resistanceassociated protein (MRP) and the canalicular multispecific organic anion transporter (cMOAT) are organic anion pumps that have been linked to cytotoxic drug resistance WeHow to SkimCoat Walls If you're a skilled drywall taper or plasterer, you probably use a hawk and trowel to skimcoat wallsWe don't expect to change your mind if you use those tools as second hands But if you're a remodeler who does only occasional skimcoating to fix wrecked walls, you know it's a tough skill to masterA Canalicular Multispecific Organic AniónTransporter (cMOAT) Antisense cDNA Enhances Drug Sensitivity in Human Hepatic Cancer Cells1 Koji Koike,2 Takeshi Kawabe, Toshiya Tanaka, Satoshi Toh, Takeshi I cimimi Morimasa Wada, Shinichi Akiyama, Mayumi Ono, and Michihiko Kuwano
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'Canalicular Multispecific Organic Anion Transporter' is one option get in to view more @ The Web's largest and most authoritative acronyms and abbreviations resourceLooking for the definition of CMOAT?In addition, cMOATtransfected cells have been reported to exhibit enhanced efflux of the natural product drug vincristine (Evers et al, 1998), and a cMOATdeficient rat strain has been reported to have decreased excretion of methotrexate into the bile (Masuda et al, 1997) Together these studies concerning MRP and cMOAT indicate that organic anion
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From sectionals and recliners to bean bags and rocking chairs, these oversized couches and chairs are so comfortable, you'll never want to get upExpression of γglutamylcysteine synthetase (γGCS) and multidrug resistanceassociated protein (MRP), but not human canalicular multispecific organic anion transporter (cMOAT), genes correlatesCOMAT Distinctive subject examinations designed to assess core osteopathic medical knowledge A series of nationally standardized subject exams, COMAT exams are designed to assess osteopathic medical students' knowledge and ability in core osteopathic medical and foundational biomedical sciences principles
Figure 4 From Physicochemical Parameters Responsible For The Affinity Of Methotrexate Analogs For Rat Canalicular Multispecific Organic Anion Transporter Cmoat Mrp2 Semantic Scholar
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Several organic anions are excreted into the bile via a canalicular multispecific organic anion transporter (cMOAT), which is hereditarily defective in mutant rats, such as the Eisai hyperbilirubinThe Monroe County Assessor's Office maintains property records for all townships The property record cards contain the property characteristics and the assessed value based on Market Value in use We also maintain sales information of properties sold from 08Present for the entire countyThe exporter ABCC2 (cMOAT, MRP2) is a membranebound protein on the apical side of enterocytes and hepatic biliary vessels that transports leukotriene C4, glutathione, some conjugated bile salts, drugs, xenobiotics, and phytonutrients The latter class includes quercetin, a bioactive flavonoid found in foods such as onions, apples, tea, and wine
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Abstract The human cMOAT gene encodes a membrane protein involved in the ATPdependent transport of hydrophobic compounds To determine whether cMOAT is associated with drug sensitivity, we transfected an expression vector containing cMOAT antisense cDNA into the HepG2 human hepatic cancer cell lineThe standard vesicular transport assay is an inhibitory assay performed with cold test articles This assay provides information on any interaction between the ABC transporter and the test article'Canalicular Multispecific Organic Anion Transporter' is one option get in to view more @ The Web's largest and most authoritative acronyms and abbreviations resource
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Human cMOAT was mainly localized in the plasma membrane of CHO/cMOAT and in the apical membrane of LLC/cMOAT The ATPdependent uptake of leukotriene C4 (LTC 4) into CHO/cMOAT membrane vesicles was enhanced compared with empty vector transfectants Km values in CHO/cMOAT membrane vesicles were 024 μM for LTC 4 and 175 μM for ATPCMOAT stands for Canalicular Multispecific Organic Anion Transporter Suggest new definition This definition appears frequently and is found in the following Acronym Finder categories Science, medicine, engineering, etc Other Resources We have 1 other meaning of cMOAT in our Acronym AtticCharlotte Moat (cmoat@comonroeinus)Personal Property Michelle Graham (mgraham@comonroeinus)Sales Disclosures Allie Goveia (agoveia@comonroeinus)Land, Classified Forest Everyone please take precautions for you and your families Stay well, stay safe!
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Porter (cMOAT) was found and designated human cMOAT Fluorescence in situ hybridization demonstrated the chromosomal locus of the gene on chromosome 10q24 The human cMOAT eDNA hybridized a 65kb mRNA that was expressed 4 to 6fold higher by three cisplatinresistant cell lines derived from various human tumors exhibiting decreased drugCharacterization of MOATC and MOATD, new members of the MRP/cMOAT subfamily of transporter proteins Belinsky MG, Bain LJ, Balsara BB, Testa JR, Kruh GD BACKGROUNDMultidrug resistanceassociated protein (MRP) and canalicular multispecific organic anion transporter (cMOAT) are transporter proteins that pump organic anions across cellular membranes and have been linked to resistanceA cDNA for rat cMOAT, a protein homologous to the multidrug resistance proteins located in the canalicular membrane of hepatocytes, has recently been characterized Molecular biological methods in diagnosis and treatment of liver diseases
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The cMOAT/MRP2/ABCC2 protein is encoded by a singlecopy gene, MRP2/cMOAT/ABCC2, on chromosome 10q24 15 The conjugated hyperbilirubinemia observed in DubinJohnson syndrome results from defective transport of bilirubin glucuronide across the membrane that separates the hepatocyte from the bile canaliculi
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